ARTICLE: Superbugs Are Growing More Resistant to Hand Sanitizers & Commonly Used Disinfectants, Scientists Warn

As World Antimicrobial Awareness Week draws to a close Purazine launches MicroSafe, an HOCl+, natural, safe, highly effective disinfectant that kills Covid-19 among other enveloped and non-enveloped viruses

 

Bacteria (such as super bugs) are learning to adapt and survive in the face of alcohol-based hand sanitisers and high-strength hospital surface disinfectants, scientists warn1.

 

“A particular group of bacteria, known as Vancomycin Resistant Enterococci (VRE), seem to have mutated to prevent alcohol from busting it into oblivion. While it's not time to ditch conventional sanitizers yet, research suggests it is time to rethink1.”

In a landmark report, the Organization for Economic Co-operation and Development (OECD) said 2.4 million people could die from superbugs by 2050 and said the cost of treating such infections would balloon to an average of $3.5 billion a year in each country included in its analysis2.

 

While a comprehensive strategy is required to fight superbug mutations, one approach is the implementation of a class of disinfectants known as Super-Oxidized Solution or HOCl, which have demonstrated the ability to kill a wide range of bacteria and viruses, including Multi Drug Resistant Bacteria such as MRSA & VRE.

 

When exposed to these solutions, the high Oxidation Reduction Potential (ORP) environment is thought to create an unbalanced osmolarity between the ion concentrations in the solution and that within unicellular organisms, further damaging membrane structures. This will cause increased membrane porosity, enabling the HOCl to penetrate (via diffusion) into the cell cytoplasm, ultimately leading to the inactivation of intracellular protein, lipids and nucleic acid, rendering the cell non-functional. It has been postulated that this mode of action leave no chance for mutation and resistance3.

 

The main reason why HOCl solutions have not been widely used is due to their highly unstable nature. Most are manufactured on-site and have a shelf life of a few hours to a couple of days at best. This limits the ability of independent laboratory testing and regulatory approvals.

 

Sonoma Pharmaceuticals, a company based in Northern California, has pioneered a method to stabilize HOCl, thereby earning the first US FDA approval for shelf-stable HOCl globally in 2003 and patented it as the revolutionary Microcyn® Technology (U.S Patent No. 9.918.477).

 

Over the past 20 years, Microcyn® Technology has earned multiple FDA, CE and Australian TGA approvals for Human Wound Care, Dermatology and High-Level Surface Disinfection.

 

Independent laboratory testings done in accordance with guidelines set forth by the U.S. EPA have determined a greater than 24 months shelf life and zero inhalation toxicity (Storage Stability Test OPPTS 830.6317 and US EPA Inhalation Toxicity test OPPTS 870.1300). Furthermore, U.S EPA tests also concluded zero, ocular, dermal and oral toxicity. The Microcyn® Technology has over 40 published studies demonstrating a safety profile nearly identical to normal saline and efficacy that out-performs conventional harsh chemical disinfectants.

 

Based on the regulatory approvals and available literature on the Microcyn® Technology, implementing it as part of a comprehensive disinfection protocol will yield significant benefits in terms of reducing the risks of Hospital Acquired Infections and general disease transmission.

 

Currently, the Microcyn® Technology is available in the UK & EU under the brand name MicroSafe® Disinfectant Solution.

 

Sources

1; https://www.sciencealert.com/superbugs-becoming-more-resistant-to-hospital-alcohol-disinfectant-sanitiser

2; https://economictimes.indiatimes.com/news/science/superbugs-to-kill-millions-by-2050-unless-countries-act/resistance-to-antibiotics/slideshow/66536086.cms

3; Eur J Clin Microbiol Infect Dis DOI 10.1007/s10096-011-1369-9